Senior Associate Dean for Faculty and Academic Affairs, School of Engineering
Professor, Chemical Engineering
Centers & Institutes:
Director, Center on Polymer Interfaces and Macromolecular Assemblies
Environmental Faculty, Woods Institute
» Curtis Frank uses spin casting, Langmuir-Blodgett deposition, and surface grafting to fabricate ultrathin films in the range of 100 to 1000 Angstroms thick in order to explore their properties. Dr. Frank also studies the biological cell membrane. In particular, Dr. Frank is working with the Department of Ophthalmology in the Stanford School of Medicine to design and synthesize a fully interpenetrating network of two different hydrogel materials that have properties consistent with application as a substitute for the human cornea: high water swellability up to 85%, tensile strength comparable to the cornea, high glucose permeability comparable to the cornea, and sufficient tear strength to permit suturing. Thus far, Dr. Frank has developed a technique for surface modification with adhesion peptides that allows binding of collagen and subsequent growth of epithelial cells. Broad questions on the relationships among molecular structure, processing protocol, and biomedical device application are being pursued.
Mason, A. F., Lohmeijer, B. G. G., Li, H., Pratt, R. C., Liao, Q., Frank, C. W., Kingsbury, K., Waymouth, R. M., Hedrick J. L.; "Organocatalytic Polymerization of Ethylene Oxide and the Controlled Synthesis of Peo-Based Hydrogel Networks." Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 47, 2, 99-100, 2006.
Malkoch, M., Vestber, R., Gupta, N., Mespouille, L., Dubois, G., Mason, A. F. Hedrick, J. L., Liao, Q., Frank, C. W., Kingsbury, D., Hawker, C. J.; "Synthesis of Well-Defined Hydrogel Networks Using Click Chemistry". Chem. Commun., 2774-2776, 2006.
Muir, B.V.O., Corten, C., Kuckling, D., Kasry, A., Knoll, W., Frank, C.W.; "Fabrication of Tunable Diffraction Gratings Based on Thermoresponsive NIPAAm Hydrogels for Grating Coupled Surface Plasmon Resonance." Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 47, 2, 1082, 2006.
Rocha-Mendoza, I., Yankelevich, D. R.,Wang, M., Bratton, C., Reiser, K. M., Frank, C. W., Knoesen, A.; "Achiral and Chiral Sum Frequency Vibrational Spectroscopy of Collagen Fibrils". CLEO/QELS, JTuD52, 2006.
Hwang, L.Y., Götz, H., Hawker, C.J., Frank, C.W.; “Glyco-acrylate Copolymers for Bilayer Tethering on Benzophenone-modified Substrates”. Colloids and Surfaces B: Biointerfaces, 54, 127-135, 2007.
Rocha-Mendoza, I., Yankelevich, D. R., Wang, M., Reiser, K. M., Frank, C. W., Knoesen A.; “Sum Frequency Vibrational Spectroscopy the Molecular Origins of the Optical Second-Order Nonlinearity of Collagen”. Biophysical Journal, 93, 12, 4433-4444, 2007.
Nederberg, F., Trang, V., Pratt, R.C., Mason, A.F., Frank, C.W., Waymouth, R.M., Hedrick, J.L.; “New Ground for Organic Catalysis: A Ring-Opening Polymerization Approach to Hydrogels”. Biomacromolecules, 8, 3294-3297, 2007.